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Article

Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse

23 Mar 2006

Abstract excerpt

Notch signaling is implicated in many developmental processes. In our current study, we have employed a transgenic strategy to investigate the role of Notch signaling during cardiac development in the mouse. Cre recombinase-mediated Notch1 (NICD1) activation in the mesodermal cell lineage leads to abnormal heart morphogenesis, which is characterized by deformities of the ventricles and atrioventricular (AV)...

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PMID: 16554359
DOI: 10.1242/dev.02344

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Source receipt: pubmed, retrieved 7 Sept 2026.

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