Telomere length and genetic analyses in population-based studies of endometrial cancer risk.

Abstract excerpt

BACKGROUND: Telomeres are protective structures at the ends of linear chromosomes, regulated by a host of associated proteins. When telomeres become dysfunctional, genomic instability ensues. The vast majority of cells undergo apoptosis, although a rare cell may survive and become tumorigenic. METHODS: The authors used conditional logistic regression to examine relative telomere length in peripheral blood...

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