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Article

In silico analysis of the two tandem somatomedin B domains of ENPP1 reveals hints on the homodimerization of the protein.

Journal of cellular physiology - 1 Nov 2012

Bellacchio Emanuele

Abstract excerpt

The homodimerization of ENPP1 is mediated by the two somatomedin B (SMB) domains of the protein through a mechanism that is yet unknown at the atomistic level. The tandem arrangement of these domains without an intermediate spacer implies their possible packing into a functional assembly, which we explored by rigid docking. To exclude potential bias in the docking search we assessed the absence of flexible...

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Identifiers

PMID: 22262087
DOI: 10.1002/jcp.24058

Genes

ENPP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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