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Article

Why is SCA12 different from other SCAs?

Cytogenetic and genome research - 1 Jan 2003

Holmes S E, O'Hearn E, Margolis R L

Abstract excerpt

Spinocerebellar ataxia type 12 (SCA12), now described in European-American and Asian (Indian) pedigrees, is unique among the SCAs from clinical, pathological, and molecular perspectives. Clinically, the distinguishing feature is early and prominent action tremor with variability in other signs. Pathologically, brain MRIs also suggest variability, with prominent cortical as well as cerebellar atrophy. Genetically,...

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PMID: 14526180
DOI: 10.1159/000072854

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