Article
SPINDLIN1 promotes cancer cell proliferation through activation of WNT/TCF-4 signaling.
Molecular cancer research : MCR - 1 Mar 2012
Wang Jing-Xue, Zeng Quan, Chen Lin, Du Ji-Chao, Yan Xin-Long, Yuan Hong-Feng, Zhai Chao, Zhou Jun-Nian, Jia Ya-Li, Yue Wen, Pei Xue-Tao
Abstract excerpt
SPINDLIN1, a new member of the SPIN/SSTY gene family, was first identified as a gene highly expressed in ovarian cancer cells. We have previously shown that it is involved in the process of spindle organization and chromosomal stability and plays a role in the development of cancer. Nevertheless, the mechanisms underlying its oncogenic role are still largely unknown. Here, we first showed that expression of...
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