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Article

Blindly using Wald's test can miss rare disease-causal variants in case-control association studies.

Annals of human genetics - 1 Mar 2012

Xing Guan, Lin Chang-Yun, Wooding Stephen P, Xing Chao

Abstract excerpt

There are four tests--the likelihood ratio (LR) test, Wald's test, the score test and the exact test--commonly employed in genetic association studies. On comparison of the four tests, we found that Wald's test, popular in genome-wide screens due to its low computational demands, exhibited a paradoxical behaviour in that the test statistic decreased as the effect size of the variant increased, resulting in a loss...

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Identifiers

PMID: 22256951
DOI: 10.1111/j.1469-1809.2011.00700.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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