Article
Integrating heterogeneous high-throughput data for meta-dimensional pharmacogenomics and disease-related studies.
Pharmacogenomics - 1 Jan 2012
Holzinger Emily R, Ritchie Marylyn D
Abstract excerpt
The current paradigm of human genetics research is to analyze variation of a single data type (i.e., DNA sequence or RNA levels) to detect genes and pathways that underlie complex traits such as disease state or drug response. While these studies have detected thousands of variations that associate with hundreds of complex phenotypes, much of the estimated heritability, or trait variability due to genetic...
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