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Article

Identification of a Novel Splice-Site variant in TACR3 (c.888 + 1G > A) Associated with Asthenozoospermia and Hypogonadotropic Hypogonadism in an Iranian Family.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Sept 2026

Saberiyan Mohammadreza, Kalantar S M, Mirfakhraie Reza, Teimori Hossein, Riazi Naser, Nejatizadeh Azim

Abstract excerpt

BACKGROUND: TACR3 encodes the receptor for neurokinin B, a key regulator of the hypothalamic-pituitary-gonadal axis. Disruption of this pathway can impair gonadotropin release and male reproductive function. Given the genetic heterogeneity of male infertility, this study aimed to identify novel variants in TACR3 that may underlie asthenozoospermia and related hormonal abnormalities. METHODS: Fifteen infertile men...

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Identifiers

PMID: 42521916
DOI: 10.1007/s43032-026-02131-6

Genes

TACR3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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Research trail→

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Identification of a Novel Splice-Site variant in TACR3 (c.888 + 1G > A) Associated with Asthenozoospermia and Hypogonadotropic Hypogonadism in an Iranian Family.PMID 42521916Read ↗

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