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Article

Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism.

The EMBO journal - 21 Mar 2012

Park Eun Chan, Ghose Piya, Shao Zhiyong, Ye Qi, Kang Lijun, Xu X Z Shawn, Powell-Coffman Jo Anne, Rongo Christopher

Abstract excerpt

Oxygen influences behaviour in many organisms, with low levels (hypoxia) having devastating consequences for neuron survival. How neurons respond physiologically to counter the effects of hypoxia is not fully understood. Here, we show that hypoxia regulates the trafficking of the glutamate receptor GLR-1 in C. elegans neurons. Either hypoxia or mutations in egl-9, a prolyl hydroxylase cellular oxygen sensor,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22252129
DOI: 10.1038/emboj.2011.499
PMCID: PMC3321172

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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