Article
The association of Toll-like receptor 4 gene polymorphisms with the development of emphysema in Japanese subjects: a case control study.
BMC research notes - 18 Jan 2012
Ito Michiko, Hanaoka Masayuki, Droma Yunden, Kobayashi Nobumitsu, Yasuo Masanori, Kitaguchi Yoshiaki, Horiuchi Toshimichi, Ikegawa Kayoko, Katsuyama Yoshihiko, Kubo Keishi, Ota Masao
Abstract excerpt
BACKGROUND: The principal role of Toll-like receptor 4 (TLR4) is the induction of immune responses to lipopolysaccharides. Previously, mice deficient in the TLR4 gene exhibited up-regulation of the NADPH oxidase system in the lungs. This resulted in increased oxidant generation and elastolytic activity, which led to pulmonary emphysema. It was suggested that TLR4 might maintain constitutive lung integrity by...
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