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Article

Ferroportin (SLC40A1) Q248H mutation is associated with lower circulating serum hepcidin levels in Rwandese HIV-positive women.

Annals of hematology - 1 Jun 2012

Masaisa Florence, Breman Candace, Gahutu Jean Bosco, Mukiibi Joshua, Delanghe Joris, Philippé Jan

Abstract excerpt

The Q248H mutation in the gene SLC40A1 which encodes for the cellular iron exporter ferroportin is relatively common in Africa. This mutation has been associated with resistance to hepcidin and therefore we hypothesized that iron-related parameters and the prevalence of opportunistic infections in HIV might be influenced by the Q248H mutation. We conducted a cross-sectional study among 200 HIV-positive women in...

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PMID: 22249207
DOI: 10.1007/s00277-011-1400-3

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