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Article

Lack of neurofibromatosis type 2 gene promoter methylation in sporadic vestibular schwannomas.

ORL; journal for oto-rhino-laryngology and its related specialties - 1 Jan 2012

Koutsimpelas D, Ruerup G, Mann W J, Brieger J

Abstract excerpt

BACKGROUND: Vestibular schwannomas (VS) are benign tumors of the nervous system that are usually sporadic but also occur in the inherited disorder neurofibromatosis type 2 (NF2). In VS, losses of chromosomal material and mutations of the NF2 gene have been established to be causative. For a subset of VS without detectable gene alterations, promoter inactivation by hypermethylation has been suggested. However,...

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Identifiers

PMID: 22249120
DOI: 10.1159/000334968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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