Article
Association of IL28B gene polymorphism with development of hepatocellular carcinoma in Japanese patients with chronic hepatitis C virus infection.
Human immunology - 1 Mar 2012
Joshita Satoru, Umemura Takeji, Katsuyama Yoshihiko, Ichikawa Yuki, Kimura Takefumi, Morita Susumu, Kamijo Atsushi, Komatsu Michiharu, Ichijo Tetsuya, Matsumoto Akihiro, Yoshizawa Kaname, Kamijo Nozomi, Ota Masao, Tanaka Eiji
Abstract excerpt
IL28B single nucleotide polymorphisms (SNPs) are associated with spontaneous and treatment-induced elimination of hepatitis C virus (HCV). To assess whether the IL28B rs8099917 SNP also affects the progression of chronic HCV infection, we genotyped 511 Japanese HCV patients, including 69 with hepatocellular carcinoma (HCC). The T/T genotype of rs8099917 was not associated with the development of HCC (p = 0.623),...
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