Article
The Caenorhabditis elegans synthetic multivulva genes prevent ras pathway activation by tightly repressing global ectopic expression of lin-3 EGF.
PLoS genetics - 1 Dec 2011
Saffer Adam M, Kim Dong Hyun, van Oudenaarden Alexander, Horvitz H Robert
Abstract excerpt
The Caenorhabditis elegans class A and B synthetic multivulva (synMuv) genes redundantly antagonize an EGF/Ras pathway to prevent ectopic vulval induction. We identify a class A synMuv mutation in the promoter of the lin-3 EGF gene, establishing that lin-3 is the key biological target of the class A synMuv genes in vulval development and that the repressive activities of the class A and B synMuv pathways are...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Epidermal Growth Factor
- Female
- Gene Expression Regulation, Developmental
- Germ Cells
- MAP Kinase Signaling System
- Mutation
- Phenotype