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Article

The Caenorhabditis elegans synthetic multivulva genes prevent ras pathway activation by tightly repressing global ectopic expression of lin-3 EGF.

PLoS genetics - 1 Dec 2011

Saffer Adam M, Kim Dong Hyun, van Oudenaarden Alexander, Horvitz H Robert

Abstract excerpt

The Caenorhabditis elegans class A and B synthetic multivulva (synMuv) genes redundantly antagonize an EGF/Ras pathway to prevent ectopic vulval induction. We identify a class A synMuv mutation in the promoter of the lin-3 EGF gene, establishing that lin-3 is the key biological target of the class A synMuv genes in vulval development and that the repressive activities of the class A and B synMuv pathways are...

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Source

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Identifiers

PMID: 22242000
DOI: 10.1371/journal.pgen.1002418
PMCID: PMC3248470

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Caenorhabditis elegans synthetic multivulva genes prevent ras pathway activation by tightly repressing global ectopic expression of lin-3 EGF.PMID 22242000Read ↗

SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegans.Semantic proximity Read ↗

Structural requirements for the tissue-specific and tissue-general functions of the Caenorhabditis elegans epidermal growth factor LIN-3.Semantic proximity Read ↗

Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans.Semantic proximity Read ↗

SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans.Semantic proximity Read ↗

Identification and classification of genes that act antagonistically to let-60 Ras signaling in Caenorhabditis elegans vulval development.Semantic proximity Read ↗

dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development.Semantic proximity Read ↗

sli-3 negatively regulates the LET-23/epidermal growth factor receptor-mediated vulval induction pathway in Caenorhabditis elegans.Semantic proximity Read ↗

A cell-specific enhancer that specifieslin-3expression in theC. elegansanchor cell for vulval developmentSemantic proximity Read ↗

Multiple levels of redundant processes inhibit Caenorhabditis elegans vulval cell fates.Semantic proximity Read ↗

Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex.Semantic proximity Read ↗

LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes.Semantic proximity Read ↗

Caenorhabditis elegans lin-13, a member of the LIN-35 Rb class of genes involved in vulval development, encodes a protein with zinc fingers and an LXCXE motif.Semantic proximity Read ↗

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