Article
Large-scale pathway-based analysis of bladder cancer genome-wide association data from five studies of European background.
PloS one - 1 Jan 2012
Menashe Idan, Figueroa Jonine D, Garcia-Closas Montserrat, Chatterjee Nilanjan, Malats Nuria, Picornell Antoni, Maeder Dennis, Yang Qi, Prokunina-Olsson Ludmila, Wang Zhaoming, Real Francisco X, Jacobs Kevin B, Baris Dalsu, Thun Michael, Albanes Demetrius, Purdue Mark P, Kogevinas Manolis, Hutchinson Amy, Fu Yi-Ping, Tang Wei, Burdette Laurie, Tardón Adonina, Serra Consol, Carrato Alfredo, García-Closas Reina, Lloreta Josep, Johnson Alison, Schwenn Molly, Schned Alan, Andriole Gerald, Black Amanda, Jacobs Eric J, Diver Ryan W, Gapstur Susan M, Weinstein Stephanie J, Virtamo Jarmo, Caporaso Neil E, Landi Maria Teresa, Fraumeni Joseph F, Chanock Stephen J, Silverman Debra T, Rothman Nathaniel
Abstract excerpt
Pathway analysis of genome-wide association studies (GWAS) offer a unique opportunity to collectively evaluate genetic variants with effects that are too small to be detected individually. We applied a pathway analysis to a bladder cancer GWAS containing data from 3,532 cases and 5,120 controls of European background (n = 5 studies). Thirteen hundred and ninety-nine pathways were drawn from five publicly...
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