Article
Population variability in CD38 activity: correlation with age and significant effect of TNF-α -308G>A and CD38 184C>G SNPs.
Molecular genetics and metabolism - 1 Mar 2012
Polzonetti Valeria, Carpi Francesco M, Micozzi Daniela, Pucciarelli Stefania, Vincenzetti Silvia, Napolioni Valerio
Abstract excerpt
CD38 (EC 3.2.2.6, NAD(+)-glycohydrolase) is a multifunctional enzyme catalyzing the synthesis and hydrolysis of cyclic ADP-ribose from NAD(+) to ADP-ribose. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. Notably, it has been linked to HIV infection, leukemias, myelomas, solid tumors, Type II Diabetes mellitus, bone metabolism, as well...
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