Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes.

Blood - 1 Mar 2012

Anur Praveen, Yates Jane, Garbati Michael R, Vanderwerf Scott, Keeble Winifred, Rathbun Keaney, Hays Laura E, Tyner Jeffrey W, Svahn Johanna, Cappelli Enrico, Dufour Carlo, Bagby Grover C

Abstract excerpt

Fanconi anemia, complementation group C (FANCC)-deficient hematopoietic stem and progenitor cells are hypersensitive to a variety of inhibitory cytokines, one of which, TNFα, can induce BM failure and clonal evolution in Fancc-deficient mice. FANCC-deficient macrophages are also hypersensitive to TLR activation and produce TNFα in an unrestrained fashion. Reasoning that suppression of inhibitory cytokine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dasatinib
Share to Fanconi Anemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group A Protein

Share to Matrix Metalloproteinases

Share to Naphthalenes

Share to Phagocytes

Share to Proto-Oncogene Proteins c-jun

Share to Small Molecule Libraries

Source

Open in PubMed Open full text

Identifiers

PMID: 22234699
DOI: 10.1182/blood-2011-06-354647
PMCID: PMC3311243

Genes

FANCC
FANCA
MAPKAPK2
MIP
TLR7
TLR8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes.PMID 22234699Read ↗

High throughput CRISPR screening identifies genes involved in macrophage viability and inflammatory pathwaysSemantic proximity Read ↗

Inflammatory Reactive Oxygen Species-Mediated Hemopoietic Suppression in Fancc-Deficient MiceSemantic proximity Read ↗

Targeting MAPAKAP2(MK2) to combat inflammation by avoiding the differential regulation of anti-inflammatory genes by p38 MAPK inhibitorsSemantic proximity Read ↗

A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explantsSemantic proximity Read ↗

Immune Complex-Mediated Cell Activation from Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients Elaborate Different Requirements for IRAK1/4 Kinase Activity across Human Cell TypesSemantic proximity Read ↗

The chemical biology of IL-12 production via the non-canonical NFkB pathwaySemantic proximity Read ↗

A Special View of What Was Almost Forgotten: p38δ MAPKSemantic proximity Read ↗

Phospholipase C δ1 in macrophages negatively regulates TLR4-induced proinflammatory cytokine production and Fcγ receptor-mediated phagocytosis.Semantic proximity Read ↗

Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shockSemantic proximity Read ↗

Regorafenib enhances antitumor immunity via inhibition of p38 kinase/Creb1/Klf4 axis in tumor-associated macrophages.Semantic proximity Read ↗

Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defenceSemantic proximity Read ↗

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.