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Article

Panhypopituitarism presenting as life-threatening heart failure caused by an inherited microdeletion in 1q25 including LHX4.

Pediatrics - 1 Feb 2012

Filges Isabel, Bischof-Renner Andrea, Röthlisberger Benno, Potthoff Christian, Glanzmann René, Günthard Joëlle, Schneider Jacques, Huber Andreas R, Zumsteg Urs, Miny Peter, Szinnai Gabor

Abstract excerpt

Clinical presentation of hypopituitarism in the neonate may be variable, ranging from absent to severe nonspecific symptoms and may be life-threatening in patients with adrenocorticotropic hormone deficiency. The LIM homeobox gene 4 (LHX4) transcription factor regulates early embryonic development of the anterior pituitary gland. Autosomal dominant mutations in LHX4 cause congenital hypopituitarism with variable...

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Source

Identifiers

PMID: 22232309
DOI: 10.1542/peds.2010-3849

Genes

LHX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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