Article
Hypopituitarism oddities: congenital causes.
Hormone research - 1 Jan 2007
Kelberman Daniel, Dattani Mehul T
Abstract excerpt
BACKGROUND: The last 15 years have witnessed an explosion in our knowledge of hypothalamo-pituitary development, acquired mainly from naturally-occurring and transgenic animal models. A complex genetic cascade dictates organ commitment, cell differentiation and cell proliferation within the anterior pituitary. Mutations in genes encoding both signalling molecules and transcription factors have been implicated in...
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