Article
Role of microRNAs 99b, 181a, and 181b in the differentiation of human embryonic stem cells to vascular endothelial cells.
Stem cells (Dayton, Ohio) - 1 Apr 2012
Kane Nicole M, Howard Lynsey, Descamps Betty, Meloni Marco, McClure John, Lu Ruifang, McCahill Angela, Breen Christopher, Mackenzie Ruth M, Delles Christian, Mountford Joanne C, Milligan Graeme, Emanueli Costanza, Baker Andrew H
Abstract excerpt
MicroRNAs (miRNAs) are short noncoding RNAs, which post-transcriptionally regulate gene expression. miRNAs are transcribed as precursors and matured to active forms by a series of enzymes, including Dicer. miRNAs are important in governing cell differentiation, development, and disease. We have recently developed a feeder- and serum-free protocol for direct derivation of endothelial cells (ECs) from human...
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