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Article

Structural and biochemical insight into glycogenin inactivation by the glycogenosis-causing T82M mutation.

FEBS letters - 3 Feb 2012

Carrizo María E, Romero Jorge M, Issoglio Federico M, Curtino Juan A

Abstract excerpt

The X-ray structure of rabbit glycogenin containing the T82M (T83M according to previous authors amino acid numbering) mutation causing glycogenosis showed the loss of Thr82 hydrogen bond to Asp162, the residue involved in the activation step of the glucose transfer reaction mechanism. Autoglucosylation, maltoside transglucosylation and UDP-glucose hydrolyzing activities were abolished even though affinity and...

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Identifiers

PMID: 22226635
DOI: 10.1016/j.febslet.2011.12.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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