Article
MICA-STR A.4 is associated with slower hearing loss progression in patients with Ménière's disease.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology - 1 Feb 2012
Gazquez Irene, Moreno Antonia, Aran Ismael, Soto-Varela Andres, Santos Sofia, Perez-Garrigues Herminio, Lopez-Nevot Alicia, Requena Teresa, Lopez-Nevot Miguel Angel, Lopez-Escamez Jose Antonio
Abstract excerpt
HYPOTHESIS: Immune response may influence hearing outcome in Ménière's disease (MD). BACKGROUND: Major histocompatibility complex class I chain-related A (MICA) encodes a highly polymorphic stress-inducible protein, which interacts with NKGD2 receptor on the surface of NK, γδ T cells and T CD8 lymphocytes. We investigated the association of MICA gene with hearing outcome in MD and its linkage disequilibrium (LD)...
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