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Article

Intronic variants in the NFKB1 gene may influence hearing forecast in patients with unilateral sensorineural hearing loss in Meniere's disease.

PloS one - 1 Jan 2014

Cabrera Sonia, Sanchez Elena, Requena Teresa, Martinez-Bueno Manuel, Benitez Jesus, Perez Nicolas, Trinidad Gabriel, Soto-Varela Andrés, Santos-Perez Sofía, Martin-Sanz Eduardo, Fraile Jesus, Perez Paz, Alarcon-Riquelme Marta E, Batuecas Angel, Espinosa-Sanchez Juan M, Aran Ismael, Lopez-Escamez Jose A

Abstract excerpt

Meniere's disease is an episodic vestibular syndrome associated with sensorineural hearing loss (SNHL) and tinnitus. Patients with MD have an elevated prevalence of several autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis and psoriasis), which suggests a shared autoimmune background. Functional variants of several genes involved in the NF-κB pathway, such as REL,...

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Topics

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Share to Disease Progression
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hearing Loss, Sensorineural

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Share to NF-kappa B p50 Subunit

Source

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Identifiers

PMID: 25397881
DOI: 10.1371/journal.pone.0112171
PMCID: PMC4232390

Genes

NFKB1
REL
TLR10
TNFAIP3
TNIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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