Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Predicting pathway perturbations in Down syndrome.

Journal of neural transmission. Supplementum - 1 Jan 2003

Gardiner K

Abstract excerpt

Comparative annotation of human chromosome 21 genomic sequence with homologous regions of mouse chromosomes 16, 17 and 10 has identified 170 orthologous gene pairs. Functional annotation of these genes, based on literature reports and computationally-derived predictions, shows that a broad range of cellular processes are represented. A goal of Down syndrome research is to determine which of these processes are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to MAP Kinase Signaling System
Share to Mice
Share to Mice, Mutant Strains

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Calcium Signaling

Share to Chromosomes, Human, Pair 21

Share to Down Syndrome

Share to Gene Expression Regulation, Enzymologic

Share to Predictive Value of Tests

Source

Identifiers

PMID: 15068236
DOI: 10.1007/978-3-7091-6721-2_2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Predicting pathway perturbations in Down syndrome.PMID 15068236Read ↗

The cognitive phenotype of Down syndrome: insights from intracellular network analysis.Semantic proximity Read ↗

Loss of Correlations among Proteins in Brains of the Ts65Dn Mouse Model of Down SyndromeSemantic proximity Read ↗

The proteins of human chromosome 21.Semantic proximity Read ↗

Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse modelsSemantic proximity Read ↗

Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse modelsSemantic proximity Read ↗

Differential gene expression studies to explore the molecular pathophysiology of Down syndrome.Semantic proximity Read ↗

Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for TherapeuticsSemantic proximity Read ↗

Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brainSemantic proximity Read ↗

Mental retardation and associated neurological dysfunctions in Down syndrome: a consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways.Semantic proximity Read ↗

Molecular basis of pharmacotherapies for cognition in Down syndrome.Semantic proximity Read ↗

Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndromeSemantic proximity Read ↗

Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.