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Functional polymorphism rs7072793 C > T affect individual susceptibility to breast cancer by modulating CD25 transcription activity.

Molecular carcinogenesis - 1 May 2013

Li Hongbin, Zhou Hongfeng, Zhang Qingyuan, Zhao Shu, Zhang Yue, Wang Yan, Liu Jinglei, Song Ying, Yu Xiaojin, Yu Yan

Abstract excerpt

Substantial evidence has demonstrated immune defects in breast cancer patients. They have decreased numbers of peripheral blood lymphocytes, but higher numbers of functionally suppressive CD4(+) CD25(+) Treg in both peripheral blood and tumor microenvironment. Constitutive high expression of CD25 is a pivotal characteristic of natural Treg cells. This study aims at investigating if CD25 variability affects breast...

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PMID: 22213266
DOI: 10.1002/mc.21865

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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