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Article

Behavior of seeds and soil in the mechanism of metastasis: a deeper understanding.

Cancer science - 1 Apr 2012

Mathot Lucy, Stenninger Johan

Abstract excerpt

The so-called "seed and soil" hypothesis proposed by Stephen Paget in 1889 to explain the metastatic behavior of cancer cells and the homing of certain cancers to "selected" sites has been a well-recognized phenomenon for over a century. What advances have been made to increase our understanding of this phenomenon and what does it really implicate in terms of targets for therapy?

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Source

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Identifiers

PMID: 22212856
DOI: 10.1111/j.1349-7006.2011.02195.x
PMCID: PMC7659190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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