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Article

Dexamethasone stimulates endothelin-1 gene expression in renal collecting duct cells.

Steroids - 1 Apr 2012

Stow Lisa R, Voren George E, Gumz Michelle L, Wingo Charles S, Cain Brian D

Abstract excerpt

Aldosterone stimulates the endothelin-1 gene (Edn1) in renal collecting duct (CD) cells by a mechanism involving the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR). The goal of the present study was to determine if the synthetic glucocorticoid dexamethasone affected Edn1 gene expression and to characterize GR binding patterns to an element in the Edn1 promoter. Dexamethasone (1μM) induced a...

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Identifiers

PMID: 22209709
DOI: 10.1016/j.steroids.2011.12.011
PMCID: PMC3303981

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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