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Article

Dexamethasone blocks nerve growth factor induction of nerve growth factor receptor mRNA in PC12 cells.

Journal of neuroscience research - 1 Jan 1992

Foreman P J, Taglialatela G, Jackson G R, Perez-Polo J R

Abstract excerpt

Glucocorticoids and nerve growth factor (NGF) have been shown to have antagonistic effects on chromaffin cells in vivo. Here we determined the effect of the synthetic glucocorticoid, dexamethasone, on levels of mRNA for the nerve growth factor receptor (NGFR) in rat PC12 pheochromocytoma cells. Following administration of dexamethasone (1 microM) there is a decline in NGFR mRNA expression. More importantly,...

Topics

Animals
Blotting, Northern
Cell Differentiation
Depression, Chemical
Dexamethasone
Gene Expression Regulation, Neoplastic
Neoplasm Proteins
Nerve Growth Factors
PC12 Cells
Phenotype
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Receptors, Cell Surface

Receptors, Nerve Growth Factor

Source

Identifiers

PMID: 1319504
DOI: 10.1002/jnr.490310108

Genes

NGF
NGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1319504-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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