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Plasminogen Activator Inhibitor-1 Polymorphism Confers a Genetic Contribution to the Risk of Recurrent Spontaneous Abortion: An Updated Meta-Analysis.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Nov 2017

Huang Zhan, Tang Wenqian, Liang Zhikun, Chen Qiaopei, Li Mingyi, Li Yingfeng, Lao Shaoxing, Pan Huimin, Huang Liying, Huang Min, Hu Xuehua, Zhao Jiangyang

Abstract excerpt

Various studies have investigated the risk of recurrent spontaneous abortion (RSA) with plasminogen activator inhibitor-1 ( PAI-1) 4G/5G polymorphism. However, the results have been somewhat contradictory. Therefore, an updated meta-analysis based on 31 studies (5617 cases and 3952 controls) was undertaken to clarify this relationship. The degree of RSA risk was estimated using the odds ratio (OR) and the 95%...

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PMID: 28395596
DOI: 10.1177/1933719117702013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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