β37Trp→Cys mutation leads to multiple new hemoglobin species in red cells.

doi:10.1016/j.clinbiochem.2011.12.001

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Article

β37Trp→Cys mutation leads to multiple new hemoglobin species in red cells.

Clinical biochemistry - 1 Feb 2012

Brennan Stephen O, King Richard I, Florkowski Christopher M

Abstract excerpt

OBJECTIVES: To determine the cause of an unusual hemoglobin (Hb) pattern detected during HbA(1)c monitoring. DESIGN AND METHOD: Hemolysate was analysed by ESI MS, and individual components purified by reverse phase HPLC. Peptide mapping was used to pinpoint the substitution and DNA sequencing to confirm the mutation. RESULTS: ESI MS of lysate showed three novel β chains with mass changes of -83, -51 and +222 Da....

Topics

Amino Acid Substitution
Chromatography, Reverse-Phase
Cysteine
Erythrocytes
Humans
Male
Middle Aged
Mutation
Peptides
Spectrometry, Mass, Electrospray Ionization
Tryptophan
beta-Globins

Source

Open in PubMed

Identifiers

PMID: 22200562
DOI: 10.1016/j.clinbiochem.2011.12.001

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