A new beta-chain variant: Hb stockholm [beta 7(A4)GluAsp] causes falsely low Hb A(1c).

doi:10.1080/03630260902861956

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Article

A new beta-chain variant: Hb stockholm [beta 7(A4)GluAsp] causes falsely low Hb A(1c).

Hemoglobin - 1 Jan 2009

Bergman Ann-Charlotte, Beshara Soheir, Byman Irene, Karim Raja, Landin Britta

Abstract excerpt

A new beta-hemoglobin (Hb) variant, Hb Stockholm [beta7(A4)GluAsp], is described. The variant was characterized by mass spectrometry and DNA sequencing. The new variant is clinically silent but interferes with Hb A(1c) quantification using ion exchange chromatography, causing a falsely low Hb A(1c) level when using the Bio-Rad VARIANT II System.

Topics

Hemoglobin A
Hemoglobins, Abnormal
Humans
Mutation
Spectrometry, Mass, Electrospray Ionization
beta-Globins

Source

Open in PubMed

Identifiers

PMID: 19373590
DOI: 10.1080/03630260902861956

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