Article
Correlation between IDH1 gene mutation status and survival of patients treated for recurrent glioma.
Anticancer research - 1 Dec 2011
Lv Shasha, Teugels Erik, Sadones Jan, Quartier Erik, Huylebrouck Mike, DU Four Stephanie, LE Mercier Marie, DE Witte Olivier, Salmon Isabelle, Michotte Alex, DE Grève Jacques, Neyns Bart
Abstract excerpt
Somatic mutations in the isocitrate dehydrogenase 1 (IDH1) gene have been frequently found in low-grade glioma and secondary glioblastoma and are associated with a significantly younger age at diagnosis and a superior overall survival. We investigated the IDH1 gene mutation status by nested PCR and denaturing gradient gel electrophoresis (DGGE) on DNA extracted from archival tumor blocks of 63 glioma patients who...
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