Article
Association of p53 and CDKN1A genotypes with endometriosis.
Anticancer research - 1 Dec 2011
Ying Tsung-Ho, Tseng Chih-Jen, Tsai Su-Ju, Hsieh Shu-Ching, Lee Hong-Zin, Hsieh Yi-Hsien, Bau Da-Tian
Abstract excerpt
BACKGROUND: The tumor suppressor p53 protein plays a critical role in different cellular processes in response to DNA damage and it is responsible for transcriptional induction of the p21 (CDKN1A/WAF1/CIP1) gene. Both p53 and p21 are thought to play major roles in the development of human malignancy. Polymorphic variants of p53 at codon 72, and CDKN1A at codon 31, have been found to be associated with cancer...
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