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Article

PIT1 upregulation by HMGA proteins has a role in pituitary tumorigenesis

23 Dec 2011

Abstract excerpt

We have previously demonstrated that HMGA1B and HMGA2 overexpression in mice induces the development of GH and prolactin (PRL) pituitary adenomas mainly by increasing E2F1 transcriptional activity. Interestingly, these adenomas showed very high expression levels of PIT1, a transcriptional factor that regulates the gene expression of Gh, Prl, Ghrhr and Pit1 itself, playing a key role in pituitary gland development...

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Identifiers

PMID: 22199144
DOI: 10.1530/erc-11-0135

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