Article
Identification and characterization of Penicillium citrinum VeA and LaeA as global regulators for ML-236B production.
Current genetics - 1 Feb 2012
Baba Satoshi, Kinoshita Hiroshi, Nihira Takuya
Abstract excerpt
In filamentous fungi, production of multiple secondary metabolites is controlled by so-called global regulators. In this study, two genes encoding homologs of VeA and LaeA, representative fungal global regulators, were identified in ML-236B-producing Penicillium citrinum. Disruption of VeA and/or LaeA and complementation clearly demonstrated that both of them played critical roles in ML-236B production by...
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