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Article

A 3D microfibrous scaffold for long-term human pluripotent stem cell self-renewal under chemically defined conditions.

Biomaterials - 1 Mar 2012

Lu Hong Fang, Narayanan Karthikeyan, Lim Sze-Xian, Gao Shujun, Leong Meng Fatt, Wan Andrew C A

Abstract excerpt

Realizing the potential of human pluripotent stem cell (hPSC)-based therapy requires the development of defined scalable culture systems with efficient expansion, differentiation and isolation protocols. We report an engineered 3D microfiber system that efficiently supports long-term hPSCs self-renewal under chemically defined conditions. The unique feature of this system lies in the application of a 3D ECM-like...

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Identifiers

PMID: 22196900
DOI: 10.1016/j.biomaterials.2011.11.077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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