Article
Interactions between β-catenin and the HSlo potassium channel regulates HSlo surface expression.
PloS one - 1 Jan 2011
Bian Shumin, Bai Jun-Ping, Chapin Hannah, Le Moellic Cathy, Dong Huiping, Caplan Michael, Sigworth Fred J, Navaratnam Dhasakumar S
Abstract excerpt
BACKGROUND: The large conductance calcium-activated potassium channel alpha-subunit (Slo) is widely distributed throughout the body and plays an important role in a number of diseases. Prior work has shown that Slo, through its S10 region, interacts with β-catenin, a key component of the cytoskeleton framework and the Wnt signaling pathway. However, the physiological significance of this interaction was not...
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