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Article

A rat model of early stage osteonecrosis induced by glucocorticoids.

Journal of orthopaedic surgery and research - 21 Dec 2011

Kerachian Mohammad Amin, Harvey Edward J, Cournoyer Denis, Chow Terry Y, Nahal Ayoub, Séguin Chantal

Abstract excerpt

BACKGROUND: Glucocorticoid (GC)-induced osteonecrosis (ON) is an important complication of medical therapy. The exact pathomechanisms of ON has not been clearly elucidated. There is a need for a reproducible animal model that better approximates the clinical scenario. METHODS: To determine the genetic susceptibility of rats to develop GC-induced femoral head ON, we evaluated 5 different inbred strains of rats...

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Identifiers

PMID: 22189040
DOI: 10.1186/1749-799X-6-62
PMCID: PMC3284440

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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