Article
A mouse model for glucocorticoid-induced osteonecrosis: effect of a steroid holiday.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Feb 2009
Yang Lei, Boyd Kelli, Kaste Sue C, Kamdem Kamdem Landry, Rahija Richard J, Relling Mary V
Abstract excerpt
Glucocorticoid-induced osteonecrosis is a common and dose-limiting adverse event. The goal of this study was to establish a mouse model of glucocorticoid-induced osteonecrosis suitable for testing the effects of different treatment strategies on its frequency. Fourteen murine strains were screened using various glucocorticoids, routes of administration, and diets. Four-week-old male BALB/cJ mice were treated with...
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