Article
Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: a European-wide case study.
Annals of the rheumatic diseases - 1 Jun 2012
Chinoy H, Adimulam S, Marriage F, New P, Vincze M, Zilahi E, Kapitány A, Gyetvai A, Ekholm L, Novota P, Remakova M, Charles P, McHugh N J, Padyukov L, Alfredsson L, Vencovsky J, Lundberg I E, Danko K, Ollier W E, Cooper R G
Abstract excerpt
OBJECTIVES: HLA-DRB1*03 is strongly associated with anti-Jo-1-positive idiopathic inflammatory myopathies (IIM) and there is now increasing evidence that Jo-1 antigen is preferentially expressed in lung tissue. This study examined whether smoking was associated with the development of anti-Jo-1 antibodies in HLA-DRB1*03-positive IIM. METHODS: IIM cases were selected with concurrent information regarding HLA-DRB1...
Topics
- Adult
- Age of Onset
- Antibodies, Antinuclear
- Europe
- Female
- Genotype
- HLA-DRB1 Chains
- Humans
- Male
- Middle Aged