Article
Genetic diversity of the Leptospiral immunoglobulin-like (Lig) genes in pathogenic Leptospira spp.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Mar 2009
McBride Alan J A, Cerqueira Gustavo M, Suchard Marc A, Moreira Angela N, Zuerner Richard L, Reis Mitermayer G, Haake David A, Ko Albert I, Dellagostin Odir A
Abstract excerpt
Recent serologic, immunoprotection, and pathogenesis studies identified the Lig proteins as key virulence determinants in interactions of leptospiral pathogens with the mammalian host. We examined the sequence variation and recombination patterns of ligA, ligB, and ligC among 10 pathogenic strains from five Leptospira species. All strains were found to have intact ligB genes and genetic drift accounting for most...
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