Article
Protein arginine methyltransferase 1-directed methylation of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen.
The Journal of biological chemistry - 17 Feb 2012
Campbell Mel, Chang Pei-Ching, Huerta Steve, Izumiya Chie, Davis Ryan, Tepper Clifford G, Kim Kevin Y, Shevchenko Bogdan, Wang Don-Hong, Jung Jae U, Luciw Paul A, Kung Hsing-Jien, Izumiya Yoshihiro
Abstract excerpt
The Kaposi sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) is a multifunctional protein with roles in gene regulation and maintenance of viral latency. Post-translational modification of LANA is important for functional diversification. Here, we report that LANA is subject to arginine methylation by protein arginine methyltransferase 1 in vitro and in vivo. The major arginine...
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