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Article

Recruitment of the <i>de novo</i> DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA

18 Sept 2006

Abstract excerpt

The Kaposi's sarcoma-associated herpesvirus LANA protein is expressed in all Kaposi's sarcoma-associated herpesvirus-infected cells, including the tumor cells of endemic and AIDS-associated Kaposi sarcoma, primary effusion lymphoma, and Castleman disease. LANA modulates cell gene expression, but the mechanisms of LANA-mediated transcriptional reprogramming are poorly understood. LANA-repressed cell genes were...

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PMID: 16983096
DOI: 10.1073/pnas.0604469103

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