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Article

Matrine modulates HSC70 levels and rescues ΔF508-CFTR.

Journal of cellular physiology - 1 Sept 2012

Basile Anna, Pascale Maria, Franceschelli Silvia, Nieddu Erika, Mazzei Marco T, Fossa Paola, Turco Maria Caterina, Mazzei Mauro

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-dependent Cl(-) channel located in the plasma membrane, and its malfunction results in cystic fibrosis (CF), the most common lethal genetic disease in Caucasians. Most CF patients carry the deletion of Phe508 (ΔF508 mutation); this mutation prevents the delivery of the CFTR to its correct cellular location, the apical (lumen-facing) membrane of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22170045
DOI: 10.1002/jcp.24028

Genes

CFTR
BAG3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Matrine modulates HSC70 levels and rescues ΔF508-CFTR.PMID 22170045Read ↗

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