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Article

Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons.

Acta neuropathologica - 1 May 2012

Taschenberger Grit, Garrido Manuel, Tereshchenko Yuliya, Bähr Mathias, Zweckstetter Markus, Kügler Sebastian

Abstract excerpt

Fibrillar αSynuclein is the major constituent of Lewy bodies and Lewy neurites, the protein deposits characteristic for Parkinson's disease (PD). Multiplications of the αSynuclein gene, as well as point mutations cause familial PD. However, the exact role of αSynuclein in neurodegeneration remains uncertain. Recent research in invertebrates has suggested that oligomeric rather than fibrillizing αSynuclein...

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Identifiers

PMID: 22167382
DOI: 10.1007/s00401-011-0926-8
PMCID: PMC3316935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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