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Article

Yeast based small molecule screen for inhibitors of SARS-CoV.

PloS one - 1 Jan 2011

Frieman Matthew, Basu Dipanwita, Matthews Krystal, Taylor Justin, Jones Grant, Pickles Raymond, Baric Ralph, Engel Daniel A

Abstract excerpt

Severe acute respiratory coronavirus (SARS-CoV) emerged in 2002, resulting in roughly 8000 cases worldwide and 10% mortality. The animal reservoirs for SARS-CoV precursors still exist and the likelihood of future outbreaks in the human population is high. The SARS-CoV papain-like protease (PLP) is an attractive target for pharmaceutical development because it is essential for virus replication and is conserved...

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Identifiers

PMID: 22164298
DOI: 10.1371/journal.pone.0028479
PMCID: PMC3229576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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