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Article

Defining function of lipopolysaccharide O-antigen ligase WaaL using chemoenzymatically synthesized substrates.

The Journal of biological chemistry - 17 Feb 2012

Han Weiqing, Wu Baolin, Li Lei, Zhao Guohui, Woodward Robert, Pettit Nicholas, Cai Li, Thon Vireak, Wang Peng G

Abstract excerpt

The WaaL-mediated ligation of O-antigen onto the core region of the lipid A-core block is an important step in the lipopolysaccharide (LPS) biosynthetic pathway. Although the LPS biosynthesis has been largely characterized, only a limited amount of in vitro biochemical evidence has been established for the ligation reaction. Such limitations have primarily resulted from the barriers in purifying WaaL homologues...

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Identifiers

PMID: 22158874
DOI: 10.1074/jbc.M111.308486
PMCID: PMC3285315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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