Article
The utility and limitation of single nucleotide polymorphism analysis on whole genome amplified mesenchymal tumour DNA in formalin fixed tumour samples.
Pathology - 1 Jan 2012
Liang Cher-Wei, Lee Yow-Shan, Marino-Enriquez Adrian, Tsui Kochung, Huang Shih-Hung
Abstract excerpt
AIMS: In the study of tumour genetics, formalin fixed, paraffin embedded (FFPE) tumours are the most readily available tissue samples and DNA derived from FFPE tissue has been validated for array comparative genomic hybridisation (aCGH) and single nucleotide polymorphism (SNP) array analysis. Furthermore, in the study of tumour precursor genetics, whole genome amplification (WGA) has been used to produce a...
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