Article
HIV-1 dual infection is associated with faster CD4+ T-cell decline in a cohort of men with primary HIV infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Feb 2012
Cornelissen Marion, Pasternak Alexander O, Grijsen Marlous L, Zorgdrager Fokla, Bakker Margreet, Blom Petra, Prins Jan M, Jurriaans Suzanne, van der Kuyl Antoinette C
Abstract excerpt
BACKGROUND: In vitro, animal, and mathematical models suggest that human immunodeficiency virus (HIV) co- or superinfection would result in increased fitness of the pathogen and, possibly, increased virulence. However, in patients, the impact of dual HIV type 1 (HIV-1) infection on disease progression is unclear, because parameters relevant for disease progression have not been strictly analyzed. The objective of...
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