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Article

Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2012

Wilmott James S, Long Georgina V, Howle Julie R, Haydu Lauren E, Sharma Raghwa N, Thompson John F, Kefford Richard F, Hersey Peter, Scolyer Richard A

Abstract excerpt

PURPOSE: To evaluate the effects of treatment with the potent mutant BRAF inhibitors GSK2118436 or vemurafenib (PLX4720) on immune responses to metastatic melanoma in tissues taken before and after treatment. EXPERIMENTAL DESIGN: Thirty-seven tumor biopsies were collected from 15 patients with unresectable American Joint Committee on Cancer stage III or IV melanoma immediately before and approximately 7 days...

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Source

Identifiers

PMID: 22156613
DOI: 10.1158/1078-0432.CCR-11-2479

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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